Dept. of Chemistry News

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Friday, 28 February 2003
Department of Exercise Science & Nutrition
Monmouth College

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Jason K. Johnson     
jjohnso3@monm.edu
(309) 457-3079


Tummy Flattening Gel - Sovage Dermalogic Laboratories

 Tummy Flattening Gel™ - Does it Bring New Confidence or Is It Just the Newest Con-artist?

     What does Sövage™ Dermalogic Laboratories declare about its product?  Sövage™ Dermalogic Laboratories claims that it's new product, Tummy Flattening Gel™ ($119), is a "topically applied, deep-penetrating concentrate specifically designed to mobilize the persistent, stubborn fat that makes your tummy bulge."  Use of this product, according to the advertisement,  is the "quickest way to capture a perfectly sculpted midsection."  The company also alleges that their merchandise is not your ordinary Epidril™-based product because the others have been "proven to emulsify fat on contact, ordinary transdermal products are simply not powerful enough to precisely target resistant abdominal fat."  Sövage™ proclaims that their patented topical gel will solve all of the problems associated with a troublesome "tummy pooch." If one does not see significant results within a 19 day period, Sövage™ offers an unconditional 30 day money back guarantee.  

This "could" be YOU!!

What is the "power" behind this Tummy Flattening Gel™? 
     This product influences fat loss in your abdominal region because of its properties associated with its "precise delivery of its ultra-concentrated Epidril™ base formulation to resistant areas of dense abdominal fat - selectively accelerating the breakdown of regional fat cells."   The use of Epidril™ has been "supported" by two experimental assessments and two U.S. patents 
(No. 4,525,359 & 4,588,724).  These trials have "proven" that Epidril™ reacts with fatty tissue and causes the discharge of large amounts of fat cells.  Epidril™ is a beta adrenergic stimulant, which speeds up the breakdown of fats, composed of lecithin and aminophylline.  These are two of the major ingredients of the Tummy Flattening Gel™.  The other ingredients include water, octyl palmitate, alcohol, glycerin, caramel color, fragence, ethylenediamine, tocophenyl acetate, carbomer, propylene glycol, BHA, propyl gallate, citric acid, DMDM hydantoin, idopropynyl, butycarbamate, yohimbe, forskolin.  To the consumer, these ingredients mean nothing, many of these chemicals have a direct effect on fat breakdown. Whether they work in this product is another question.  

How does this product affect metabolism and its relationship to fat loss?
     The main components of this product are lecithin and aminophylline, which make up Epidril™.  Lecithin is important in emulsification of cholesterol during fatty acid metabolism and leads to the excretion of bile salts.  It also helps in limiting fat from building up in the liver and helps in the conversion of fat to energy.  Lecithin does this by directing aminophylline to areas where fat has accumulated.  Aminophylline is commonly used in asthma medication as a stimulant.  Aminophylline acts in a similar way that other primary messengers, such as caffeine and epinephrine, would act by increases the amount of cAMP in fat cells, which activates triacylglycerol lipase and breaks down the triacylglycerol to acetyl-CoA and onto ATP.  The chemicals in Epidril™ allow fats to be effectively digested and disperse the adipose into water or the bloodstream for removal.  Glycerin, another name for glycerol,  is another primary ingredient in this product.  Glycerin is a component of triacylglycerols, that is responsible for binding to the fatty acid chains and transporting them.  After fatty acids are broken down, the glycerol can enter the gluconeogenesis pathway to make glucose.  This glucose can enter the glycolytic pathway and react with acetyl-CoA, which results from the breakdown of fats, or be stored as glycogen.  Therefore, the glycerol in the product keeps the acetyl-CoA, produced by lipid metabolism, to be broken down into energy.  Yohimbe is a alpha-2-adrenergic inhibitor.  This chemical counteracts the decrease in lipolysis that is usually associated with alpha adrenergic receptor.  Forskolin is a beta-1-adrenergic stimulator, which targets the adipocytes and increases lipolysis.  This creates a dramatic increase in lipolysis.  The localized delivery of these chemicals encourages fat metabolism, which is normally a slow process.  This increase in fatty acid breakdown also creates an increase in the presence of ketone bodies, which cause an influx in energy as well.            
Should this product work?

     Hypothetically speaking, this product should have some affect of the metabolism of fat, based on the properties associated with a number of its ingredients.  As the company states in the advertisement, when added to a culture of adipose tissue, "the cells deflate as they release their stored fat-very similar to the way a balloon deflates when stuck with a pin."  This description may be a little far-fetched, but the product should create fat loss.  However, this product will not work because of the mode of application associated with it.  This is a topical gel, which means that in order for the product to work, its ingredients must travel through the skin and large amounts of tissue to reach the fat deposit.  Although this product is "concentrated," it still does not possess the properties that would be needed to diffuse across the external layers of tissue.  
     If any results did occur, they would be short term and could result from water loss created by the product.  Furthermore, Sövage advises that consumers must "help burn off the released fat by exercising or decreasing caloric intake so circulating fat is not re-deposited." Any form of increased exercise and/or adhesion to a healthy diet should lead to visible results, which the product is not responsible for.  Basically, Sövage is stating that their product will not work only, but the results will occur with the help of exercise and improved diet.             
Would I recommend this product?
    
First of all, the company states that the product can produce these miraculous results.  However, there is a lack of support for these horrendous claims.  I find it hard to believe that only two trials give enough support to the case that Epidril™ is the answer to everyone's fat problems.  Additionally, there is little information about this product available to the general public and no long term studies have been conducted to determine possible side effects.  Tummy Flattening Gel™ has not been evaluated by the Food and Drug Administration.  Since this product is applied to the skin, the chemicals have to travel through many layers of skin to reach the fat deposits.  The chances that the product reaches the fat cells is an unlikely occurrence.  I would not recommend this product for two reasons, first, results are unlikely and if they did occur, they would not be related to the use of Tummy Flattening Gel™ and secondly, the product is new and little is known about it.  By purchasing this product, one-hundred nineteen dollars of your hard earned money would be wasted.    

References: 
Mathews, Christopher K., et. al.  Biochemistry: 3rd Edition.  San Francisco: 
      Addison Wesley Longman, Inc.  

Sövage Dermalogic Laboratories. "Patented Topical Gel Reduces Tummy Fat."   
      www.sovage.com

United States Patent and Trademark Office.  www.uspto.gov.


Disclaimer: This fictitious department of Monmouth College.  This product analysis is part of a class assignment for Advanced Biochemistry, is not responsible for any error that may occur in this article.