Current Study
Currently, many clinical trials are underway in order to determine the effectiveness and safety of using genetic therapy. For example, currently therapeutic genetic techniques are being performed to treat peripheral artery disease (PAS). PAS causes pain while walking or sitting and increases the prevalence and likelihood to develop ulcers and gangrene in the limbs. Though methods of treatment such as exercise and certain medicines can be influential, some individuals are unable to recognize substantial benefits from normal treatment options. The quality of life for some individuals with severe cases is poor and genetic therapy offers a potential solution for this issue. A PDF of this clinical study can be obtained from the link at the bottom of the page.
Naked DNA was used as a vector in order to transfer genetic information that would induce increased expression of vascular endothelial growth factor or VEGF. The increased amount of VEGF allows for increased blood vessel growth which provides better circulation for PAS patients. This study has shown that this method of gene therapy is safe for use in humans and is an effective treatment method for PAS.
Sources used
Vascular endothelial growth factor-induced angiogenic gene therapy in patients with peripheral artery disease
http://www.e-emm.org/article/article_files/EMM036-04-06.pdf
Family Doctor website: Peripheral Arterial Disease and Claudication
http://familydoctor.org/008.xml
This website was created for the course Honors 210:The Ideal at Monmouth College.