NIKO Anabolic steroids are another name for synthetic substances related to the male sex hormones (androgens). They promote the growth of skeletal muscle (anabolic effects) and the development of male sexual characteristics (androgenic effects). Anabolic steroids were developed in the late 1930s primarily to treat hypogonadism, a condition in which the testes do not produce sufficient testosterone for normal growth, development, and sexual functioning. The primary medical uses of these compounds are to treat delayed puberty, some types of impotence, and wasting of the body caused by HIV infection or other diseases. During the 1930s, scientists discovered that anabolic steroids could help the growth of skeletal muscles in laboratory animals, which led to use of the steroids by bodybuilders and weightlifters and then by athletes in other sports. Steroid abuse has become so common in athletics that it affects probably 7out of every 10 sporting events. More than 100 different anabolic steroids have been developed, but they require a prescription to be used legally in the United States. Most steroids that are used illegally are smuggled in from other countries, illegally diverted from U.S. pharmacies, or devloped in laboratories. Testosterone is the most important representative of the male sex hormones collectively called androgens. Using cholesterol as a base, the male gonads (testes) produce between 4 and 10 mg of testosterone per day. Testosterone itself is responsible for three major functions in animals. 1) The development of secondary male sex characteristics also called the androgenic functions of testosterone. Some examples of these characteristics are increased growth of body hair, beard growth, deep voice, increased production of sebaceous glands, development of the penis, aggressiveness, sexual behavior, libido, and the maturation of sperm. 2) Promotion of the protein biosynthesis that are responsible for the highly anabolic characteristics of testosterone. This function is very important. It accelerates muscle buildup, increases the formation of red blood cells, speeds up regeneration, and speeds up recovery time after injuries or illness. It also stimulates the entire metabolism which results in the burning of bodyfat. 3) Inhibition of the gonad regulating cycle, including the hypothalamohypophysial testicular axis, which regulates the amount of testosterone produced in the organism. If the testosterone level in the blood is high, the testes will signal the hypothalymus to release less LHRH (leutenizing hormone releasing hormone). Thus the hypophysis releases less gonadotropin LH (leutenizing hormone) and FSH (folic stimulating hormone). Consequently, the Leydig's cells in the testes reduces the production of testosterone. |